| 1 | Indiana Connections Academy Indianapolis | 39.3:1 | Other | Indiana Connections Academy | 5,376 |
| 2 | Indiana Gateway Digital Academy Clarksville | 30.8:1 | Other | Clarksville Community School Corp | 5,318 |
| 3 | Carmel High School Carmel | 17.8:1 | High | Carmel Clay Schools | 5,239 |
| 4 | Indiana Digital Jr and High School Modoc | 35.8:1 | Other | Union School Corporation | 4,166 |
| 5 | Penn High School Mishawaka | 20.1:1 | High | Penn-Harris-Madison School Corp | 3,687 |
| 6 | North Central High School Indianapolis | 16.1:1 | High | MSD Washington Township | 3,682 |
| 7 | Fishers High School Fishers | 23:1 | High | Hamilton Southeastern Schools | 3,590 |
| 8 | Avon High School Avon | 19.5:1 | High | Avon Community School Corp | 3,523 |
| 9 | Hamilton Southeastern Hs Fishers | 21.2:1 | High | Hamilton Southeastern Schools | 3,504 |
| 10 | Franklin Central High School Indianapolis | 21:1 | High | Franklin Township Com Sch Corp | 3,438 |
| 11 | Warren Central High School Indianapolis | 18.5:1 | High | MSD Warren Township | 3,391 |
| 12 | Brownsburg High School Brownsburg | 19.1:1 | High | Brownsburg Community School Corp | 3,355 |
| 13 | Ben Davis High School Indianapolis | 18.5:1 | High | MSD Wayne Township | 3,315 |
| 14 | Noblesville High School Noblesville | 16.7:1 | High | Noblesville Schools | 3,291 |
| 15 | Pike High School Indianapolis | 16.5:1 | High | MSD Pike Township | 3,188 |
| 16 | Elkhart High School Elkhart | 17:1 | High | Elkhart Community Schools | 3,073 |
| 17 | Crown Point High School Crown Point | 22.5:1 | High | Crown Point Community School Corp | 3,038 |
| 18 | Center Grove High School Greenwood | 21.1:1 | High | Center Grove Community School Corp | 2,956 |
| 19 | Westfield High School Westfield | 17.5:1 | High | Westfield-Washington Schools | 2,948 |
| 20 | Lake Central High School Saint John | 20.2:1 | High | Lake Central School Corporation | 2,926 |
| 21 | Lawrence North High School Indianapolis | 19.7:1 | High | MSD Lawrence Township | 2,799 |
| 22 | Carroll High School Fort Wayne | 19.5:1 | High | Northwest Allen County Schools | 2,623 |
| 23 | Lawrence Central High School Indianapolis | 19.6:1 | High | MSD Lawrence Township | 2,517 |
| 24 | Perry Meridian High School Indianapolis | 18.8:1 | High | Perry Township Schools | 2,455 |
| 25 | Southport High School Indianapolis | 17.6:1 | High | Perry Township Schools | 2,431 |
| 26 | Homestead High School Fort Wayne | 20.2:1 | High | MSD Southwest Allen County Schls | 2,382 |
| 27 | Columbus North High School Columbus | 13.4:1 | High | Bartholomew Con School Corp | 2,360 |
| 28 | Arsenal Technical High School Indianapolis | 17.4:1 | High | Indianapolis Public Schools | 2,360 |
| 29 | Zionsville Community High School Zionsville | 18.9:1 | High | Zionsville Community Schools | 2,338 |
| 30 | Jeffersonville High School Jeffersonville | 17.8:1 | High | Greater Clark County Schools | 2,202 |
| 31 | William Henry Harrison High School West Lafayette | 17.5:1 | High | Tippecanoe School Corp | 2,194 |
| 32 | Portage High School Portage | 19:1 | High | Portage Township Schools | 2,163 |
| 33 | Northrop High School Fort Wayne | 20.7:1 | High | Fort Wayne Community Schools | 2,145 |
| 34 | Whiteland Community High School Whiteland | 16.8:1 | High | Clark-Pleasant Community Sch Corp | 2,144 |
| 35 | Indiana Digital Elementary Modoc | 24.1:1 | Elementary | Union School Corporation | 2,125 |
| 36 | Merrillville High School Merrillville | 16.3:1 | High | Merrillville Community School Corp | 2,115 |
| 37 | Valparaiso High School Valparaiso | 20.8:1 | High | Valparaiso Community Schools | 2,089 |
| 38 | Warsaw Community High School Warsaw | 14.5:1 | High | Warsaw Community Schools | 2,077 |
| 39 | Jefferson High School Lafayette | 15:1 | High | Lafayette School Corporation | 2,042 |
| 40 | Cloverdale Distance Learning Academy Cloverdale | — | Elementary | Cloverdale Community Schools | 1,986 |
| 41 | Decatur Central High School Indianapolis | 16.3:1 | High | MSD Decatur Township | 1,974 |
| 42 | Adams High School South Bend | 15.9:1 | High | South Bend Community School Corp | 1,966 |
| 43 | Castle High School Newburgh | 18.9:1 | High | Warrick County School Corp | 1,953 |
| 44 | Chesterton Senior High School Chesterton | 20.2:1 | High | Duneland School Corporation | 1,937 |
| 45 | R Nelson Snider High School Fort Wayne | 21.3:1 | High | Fort Wayne Community Schools | 1,927 |
| 46 | Plainfield High School Plainfield | 19.8:1 | High | Plainfield Community School Corp | 1,856 |
| 47 | Mccutcheon High School Lafayette | 15.7:1 | High | Tippecanoe School Corp | 1,835 |
| 48 | New Albany Senior High School New Albany | 17.1:1 | High | New Albany-Floyd Co Con Sch | 1,821 |
| 49 | Hammond Central High School Hammond | 19.4:1 | High | School City of Hammond | 1,814 |
| 50 | Laporte High School LaPorte | 16:1 | Other | LaPorte Community School Corp | 1,807 |